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Publications > Détail

R.DEFAY - L.PAPOZ - S.BARNY (1998)

HORMONAL STATUS AND NIDDM IN THE EUROPEAN AND MELANESIAN POPULATIONS OF NEW CALEDONIA : A CASE-CONTROL STUDY

Résumé :

OBJECTIVE : To assess ethnic differences in androgenic status related to non insulin dependent diabetes mellitus (NIDDM) in male and female Melanesians and Europeans of New Caledonia. DESIGN : This is a case-control study nestes in a prevalence study for diabetes mellitus in the multiracial population of New Caledonia. SUBJECTS : 186 male subjects were included in the survey (77 Melanesians and 116 Europeans in each case and control group). Each case and control group included 104 female Melanesian subjects (69 premenopausal and 35 post-menopausal). METHODS : Diabetic subjects were matched for age, gender, etnic group and location, with healthy normoglycaemic subjects. Testosterone levels in men and sex hormone-binding globulin ( SHBG) levels in women (measured by radioimmunoassay, RIA ) were compared between NIDDM and control subjects in relation to obesity, central adiposity and insulin levels. RESULTS : In both ethnic groups, NIDDM was associated with the lower testosterone levels but there was a marked difference among Europeans.Testosterone was negatively associated with the body mass index (BMI) (r=-O,35,P<0.01) and fasting insulin ( r=-0,37, P<0.001) in control Melanesians only. In Melanesian women , NIDDM was associated with lower SHBG levels in pre-and post menopausal women ( P< 0.001). SHGB mean level was not associated with menopausal status. CONCLUSION : Our results confirm in a Pacific population that NIDDM is associated with low levels of testosterone in men and low levels in SHGB in women. In contrast to white populations, Melanesian women have a more androgenic profile, whatever their menopausal status.

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