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Publications > Détail

MA Bouldouyre:F Baumann:A Berlioz-Arthaud: E Chungue:F Lacassin (2006)

FACTORS OF SEVERETY AT ADMISSION DURING AN EPIDEMIC OF DENGUE 1 IN NEW CALEDONIA (SOUTH PACIFIC) IN 2003

Résumé :

We report a retrospective study of an epidemic of dengue in New Caledonia ( South Pacific) in 2003 among adult inpatients. The aim wa to establish clinical and biological criteria for the severity of the infection at the time of admission. During 7 months, all inpatients older than 15 y having a laboratory-confirmed diagnosis of dengue fever (IgM or PCR)were included (n=170). Two groups were defined: severe cases ( death and/or transfer to intensive care unit, n=24) and benign cases ( n=146). Data were analysed using Epi Info sofware.Univariate analysis showed that shock, haemorrage and neurological complications were significantly more frequent in serious cases, respectively 37,5% vs 0,7%,62,5%,vs 32,2%, 25% vs 9,6% (p<0,05).Relevant biological critetria were : creatinin>140umol/l (OR 12 (95% CI 3,93-37,44)), free bilirubin>18umol/1(OR 12,69 (95% CI 2,88-59,5),amylase>220 UI/l (OR 27,34 (95%CI4,57-210)) and platelets <45,00/mm3 5or 4,35 (95% CI 1,43-1,42)) with p<0,005 (VPP=100% for association of 3 critetria. We suggest this combination of 4 biological criteria inclines to severity.

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